Keep in mind that fat suppression (or water excitation) methods will not suppress "shine-though" of hematomas, CSF-flow phenomena, motion, or gadolinium — all of which may be much more troublesome than fat. While keeping an open mind toward new developments, I therefore do not recommend these methods be used for routine TOF MRA.
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An interesting new TOF saturation technique called BeamSat TOF is available as a product on Hitachi high-field systems. BeamSat TOF allows users to place a cylindrical beam sat pulse over a specific artery while performing a 3D TOF study over a region supplied by several arteries. Signal from that one blood supply will be suppressed, allowing location of sources of blood flow to be identified. For example, a BeamSat Pulse may be placed sequentially over each carotid and vertebral artery to evaluate the contribution of each vessel to portions of the brain or a vascular malformation. For more information, the reader should follow this link to the Hitachi web site.
Gizewski ER, Ladd ME, Paul A, et al. Water excitation: a possible pitfall in cerebral time-of-flight angiography. AJNR Am J Neuroradiol 2005; 26:152-155.
Mirowitz SA. Apparent vascular occlusion on cranial TOF MRA with peripheral presaturation technique. J Comput Assist Tomogr 1993;17:927–931.
What are the major TOF MR artifacts should we know about?